Genetic analysis, structural modeling and direct coupling analysis suggest a mechanism for phosphate signaling in E. coli
Authors: Stewart Gardner, Justin Miller, Tanner Dean, Tanner Robinson, McCall Erickson, Perry Ridge, William McCleary
BMC Genetics
12 Citations
Article Accesses: 912
Novelty of Approach
-Assesses components of phosphate signal
-Utilizes both a wet lab and bioinformatics approach to confirm signals
Results
-Confirmed PhoU and PhoR components in phosphate signaling in E. coli
-Provided statistical validation (DCA mutual information) of empirical results
Implications
-Signaling sites have been identified
-May lead to PhoU mediated modification of PhoR activity