Missing something? Codon aversion as a new character system in phylogenetics
Authors: Justin Miller, Ariel Hippen, Jonathon Belyeu, Michael Whiting, Perry Ridge
Bioinformatics
February, 2017
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Novelty of Approach
-Uses codon aversion in orthologs to recover phylogenies
-Compares strength of phylogenetic signal in different codons
-Analyzes 17,717 orthologs across 72 tetrapods
Results
-Phylogenetic signal of stop codons is most congruent with the Open Tree of Life
-Phylogenetic signal not due to single-instance codons
-Codon usage is largely conserved throughout tetrapods.
Implications
-Novel phylogenetic character state
-Might be used in maximum likelihood or alignment-free methods
-Some codon usages are more phylogenetically conserved than others
Number of Genes Used versus Number of Clades Recovered
Stop Codon Clades Recovered Using Fewer Genes